Mac OS X 10.9 Mavericks wxPython Python 2.7 Quick Start
The Unix Tutorial shows you Step-by-Step How to Install and Getting-Started with wxPython 3 Classic for Python 2.7 and Cocoa API on Mac OS X 10.9 Mavericks Desktop.
wxPython is the best and most mature cross-platform GUI toolkit, given a number of constraints.
The only reason wxPython isn’t the standard Python GUI toolkit is that Tkinter was there first.

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Download wxPython Python 2.7 for macOS.
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Double-Click on .pkg to Mount.
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Double-Click on Package Installer.
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Follow the Installation Wizard.
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Getting-Started with wxPython Mac OS X.
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